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Dextrose Anhydrous vs. Monohydrate: A Technical Guide for Pharmaceutical and Food Applications
Dec.19.2025

The Fundamental Role of Dextrose in Industry

Dextrose (D-glucose) is perhaps the most versatile carbohydrate in the world. However, for a B2B procurement officer or a formulation scientist, "Dextrose" is not a single product. The choice between Anhydrous and Monohydrate forms can be the difference between a stable, high-quality product and a manufacturing failure.

While both are chemically D-glucose, their physical properties—specifically their water content—dictate their use in everything from life-saving intravenous (IV) drips to high-volume food production.

Dextrose Monohydrate: The Workhorse of Oral Dosage

Dextrose Monohydrate contains one molecule of water of crystallization for every molecule of glucose. This makes it the more cost-effective and widely used form for:

  • Oral Rehydration Salts (ORS): Its rapid solubility and sweetening power make it the ideal carrier for electrolytes.

  • Nutraceutical Tablets: It acts as a filler and binder. Our Monohydrate grade is processed to ensure excellent flowability, preventing the "clogging" of hoppers in high-speed tableting.

  • Food & Beverage: Used for its fermentation properties and as a humectant in baked goods.

Dextrose Anhydrous: Precision for Sensitive Formulations

Dextrose Anhydrous is produced by the recrystallization of dextrose at temperatures above 60°C to ensure the absence of water. This version is a "premium" grade used where moisture is a dealbreaker.

  • Injectables and IV Fluids: This is the most critical application. Our Dextrose Anhydrous is manufactured in a controlled environment to ensure it is Pyrogen-Free and meets the strict Endotoxin limits required by USP/EP/BP for parenteral use.

  • Moisture-Sensitive Actives: If you are formulating a tablet with an API (Active Pharmaceutical Ingredient) that degrades in the presence of water (like certain vitamins or antibiotics), Dextrose Anhydrous is the only choice to ensure shelf-life stability.

  • Direct Compression (DC): We offer a specific granulated Anhydrous grade that provides superior "compactibility," allowing for hard tablets with low friability even at low compression forces.

Quality Standards: Beyond the Basics

When sourcing Dextrose at scale, "purity" goes beyond just the assay percentage. We focus on three critical metrics that many suppliers overlook:

  1. Clarity of Solution: For liquid formulations, the solution must be crystal clear and free of "black specks" or insoluble matter. Our filtration process ensures 100% clarity.

  2. Sulfated Ash and Heavy Metals: Our Dextrose is rigorously tested to ensure it meets the ultra-low limits required for long-term clinical safety.

  3. Microbiological Purity: We provide full testing for TAMC (Total Aerobic Microbial Count) and TYMC (Total Yeast and Mold Count), ensuring our product is safe for even the most sensitive pharmaceutical applications.

Why Partner With Us for Your Dextrose Needs?

Dextrose is a high-volume commodity, but we treat it with the precision of a specialty API. We offer:

  • Climate-Controlled Storage: Preventing the caking and clumping that often occurs with dextrose during transit.

  • Custom Particle Sizes: Whether you need a fine powder for rapid dissolution or granules for flowability.

  • Regulatory Support: Full documentation for GMP audits and international imports.

Product link:https://arshinepharma.com/productdetail/Dextrose-Anhydrous-Monohydrate

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