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Brimonidine L-tartrate
Brimonidine L-tartrate
CAS No.:70359-46-5
Molecular Formula:C15H16BrN5O6
Molecular Weight:442.22
PRODUCT NAME:Brimonidine L-tartrate

Brimonidine L-tartrate is a pharmaceutical compound used primarily in ophthalmic solutions to treat conditions like glaucoma and ocular hypertension. It falls under the category of alpha-adrenergic agonists and works by decreasing the fluid production in the eye, thereby reducing intraocular pressure.

A typical product description for Brimonidine L-tartrate powder might include:

  1. Chemical Name: Brimonidine L-tartrate
  2. Chemical Formula: C11H10BrN5.C4H6O6
  3. Appearance: White to off-white crystalline powder
  4. Solubility: Soluble in water and sparingly soluble in alcohol.
  5. Pharmacological Action: Acts as an alpha-adrenergic agonist, selectively binding to alpha receptors in the eye, thereby reducing intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow.
  6. Medical Uses: Formulated into ophthalmic solutions for the treatment of glaucoma and ocular hypertension.
  7. Dosage Forms: Typically available in the form of eye drops or ophthalmic solutions.
  8. Dosage and Administration: The dosage and frequency of administration depend on the severity of the condition and the doctor's prescription. Usually, it's applied topically to the affected eye(s) as directed.
  9. Safety and Precautions: While generally safe, Brimonidine L-tartrate may cause side effects such as ocular irritation, dry mouth, fatigue, or changes in blood pressure. It should be used cautiously, especially in patients with cardiovascular diseases or depression.
  10. Storage: It should be stored in a dry place at room temperature, away from light and moisture.

As with any medication, it's crucial to use Brimonidine L-tartrate as prescribed by a healthcare professional to avoid potential adverse effects and to maximize its therapeutic benefits for the specific eye condition being treated.

Product Name

Brimonidine Tartrate

CAS No.

70359-46-5

Production Date

Mar.09,2022

Report Date

Mar.14,2022

Batch No

IFP07-220301

Retest Date

Mar.08,2024

Quantity

10.3Kg

Packing

1kg/Alu

minium 

bag

 

ITEMS

SPECIFICATION

RESULTS

Appearance

White or slightly yellowish or slightly brownish powder

Conforms

Identification

A:Specific optical rotation

B:Infrared absorption spectrophotometry

Conforms

Conforms

Solubility

Soluble in water,practically insoluble in anhydrous ethanol and in toluene

Conforms

Loss on Drying

≤0.50%

0.25%

Heavy Metals

≤20ppm

Conforms

Sulfated Ash

≤0.20%

0.09%

Specific Optical Rotation

+9.0°  -  +10.5°

+9.8°

 

Residual Solvents

Bromobenzene≤290ppm

Acetone≤3000ppm

Conforms

Conforms

 

 

 

 

 

Related Substances

Specified impurities:

N-(imidazolidin2ylidene)quinoxalin-6-amine≤0.1% 5-bromoquinoxalin-6-amine≤0.1%

Quinoxalin-6-amine≤0.1%

1-(5-bromoquinoxalin-6-yl)thiourea≤0.1%

2-(5-bromoquinoxalin6yl)guanidine≤0.1%

5-bromo-N-(1H-imidazol-2-yl)Quinoxalin-6-amine≤0.1% -(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl)urea≤0.19 Unspecified impurities≤0.1%

Total≤0.2%

 

Conforms

Conforms

Conforms

Conforms

Conforms

Conforms

Conforms

Conforms

0.14%

Assay(On Dried 

Basis)

99.0%-101.0%

100.1%

Packaging and Storage

Preserve in tight containers,protected from light

Conclusion

The product complies with BP2015 Standard

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