Sitagliptin is an oral antidiabetic medication belonging to the class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It is primarily used in the management of type 2 diabetes mellitus to help control blood sugar levels.
As a DPP-4 inhibitor, Sitagliptin works by inhibiting the enzyme DPP-4, which is responsible for breaking down incretin hormones in the body. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play an essential role in regulating blood sugar levels after meals. By inhibiting DPP-4, Sitagliptin allows these hormones to remain active for a longer duration, leading to increased insulin secretion and reduced glucagon release from the pancreas. This mechanism helps lower blood glucose levels and improves glycemic control in patients with type 2 diabetes.
Sitagliptin is available in tablet form and is typically taken once daily, with or without food, as prescribed by a healthcare provider. It can be used alone or in combination with other antidiabetic medications, such as metformin or sulfonylureas, to achieve better blood sugar control.
Key features and benefits of Sitagliptin:
1:Blood Sugar Control: Sitagliptin helps reduce blood glucose levels by increasing insulin secretion and decreasing glucagon release, especially after meals.
2:Weight Neutral: Unlike some other antidiabetic medications, Sitagliptin is considered weight-neutral, meaning it does not lead to significant weight gain or loss.
3:Lower Risk of Hypoglycemia: When used alone, Sitagliptin has a lower risk of causing hypoglycemia (low blood sugar) compared to certain other antidiabetic medications.
4:Convenient Dosage: The once-daily dosing of Sitagliptin makes it convenient for patients to adhere to their treatment regimen.
5:Well-Tolerated: Sitagliptin is generally well-tolerated, and the most common side effects may include mild headaches, upper respiratory tract infections, and gastrointestinal symptoms like nausea or stomach discomfort.